Understanding ALD ( Advanced Liver Disease)
Cirrhosis is a chronic liver disease often associated with alcoholism. After heart disease and cancer, cirrhosis is the third most common cause of death in people aged 45-65 years.
Cirrhosis is a general term for end-stage liver disease, which can have many causes and which disrupts normal liver tissue. Cirrhosis has no cure, but removing the ultimate cause can slow the disease.
Alcohol can poison all living cells and cause your liver cells to become inflamed and die. Their death leads your body to form scar tissue around veins of your liver. Healing liver cells (nodules) also form and press on the liver veins.
Post Necrotic Cirrhosis
Hepatitis, a viral infection of the liver, usually causes this disease, although poisonous substances may also cause it. Two types of hepatitis, hepatitis B or hepatitis C, cause 25-75% of these cases. Large areas of scar tissue mix with large areas of healing nodules.
When small tubes that help you digest food become blocked, your body mistakenly turns on itself and reacts against these bile tubes. Gallstones often block tubes and cause this type of cirrhosis. The disease usually affects women aged 35-60 years.
Your heart is a pump that pushes blood throughout your body. When your heart doesn't pump well, blood "backs up" into the liver. This congestion causes damage to your liver. It may become swollen and painful. Later it becomes hard and less painful. The cause of the heart failure may be from heart valve problems, smoking, or infection of the heart muscle or the sac around the heart.
Protein Deficiency Induced by Cirrhosis
Malnutrition in cirrhosis is associated with major complications that include sepsis, uncontrolled ascites, hepatic encephalopathy (HE), spontaneous bacterial peritonitis, and hepatorenal syndrome that develop in 65% of malnourished patients versus 12% of well-nourished patients. Malnutrition in cirrhosis consists of a loss of skeletal muscle and adipose tissue mass.
A high prevalence of malnutrition has been reported in patients with cirrhosis in studies in which visceral protein status and immunologic measures are included in the nutritional assessment.
Liver fibrosis is a progressive pathological process in which wound-healing myofibroblasts of the liver respond to injury by promoting the replacement of normal hepatic tissue with a scar-like matrix composed of cross-linked collagen.
Hepatic stellate cells (HSCs) are quiescent in a healthy liver and play a central role in the storage of vitamin A. When injury occurs, HSCs become activated and transdifferentiate into myofibroblasts.
Which express α-smooth muscle actin (α-SMA). Accumulated evidence suggests that the activation of HSCs is a key step in the development of liver fibrosis, and hepatic fibrosis was once considered irreversible.
By contrast, Advanced liver fibrosis is potentially reversible via the induction of HSC apoptosis. Consequently, there is now considerable interest in promoting HSC apoptosis and in the discovery of drugs that will induce HSC apoptosis in a selective manner.
NK Cell Proliferation
Natural killer (NK) cells are lymphocytes of the innate immune system and are present among total blood lymphocytes and in various tissues, including the bone marrow, spleen, liver, intestine, placenta and lung.
The decision to kill a target cell depends on the net balance of signals delivered by inhibitory and activating receptor molecules that are expressed on the NK cell surface. The inhibitory receptors, which subsequently inactivate NK cell functions, include killer Ig-like receptors, Ly-49A and CD94/NKG2 receptors that recognize MHC class I molecules (inhibitory ligands).
Healthy liver NK cells play critical roles in controlling liver fibrogenesis by recognizing and killing activated HSCs. NK cells have been shown to selectively recognize and kill early activated HSCs rather than quiescent or fully activated HSCs (myofibroblasts). In addition, the anti-fibrogenic effects of NK cells have been shown to be suppressed during advanced liver injury due to the increased production of transforming grwowth factor-beta (TGF-β) in intermediately activated HSCs. Thus, down-regulation of the activities of NK cells may contribute to the progression of liver fibrosis.
Cordyceps is capable of inhibiting inflammation and regulating the immune system. The number and cytotoxicity of NK cells have been reported to increase significantly in response to C. sinensis both in vitro and in vivo. Abundant amounts of bioactive components are present in Cordyceps such as proteins, fats, essential amino acids, volatile oils, carotenoids, phenolic compounds, flavonoids, minerals (Fe, Ca, Mg, Ni, Sr, Na, Ti, Pi, Se, Mn, Zn, Al, Si, K, Cr, Ga, V and Zr), vitamins (B1, B2, B12, E and K) as well as various types carbohydrates like monosaccharides, oligosaccharides, polysaccharides, sterols, nucleosides, etc. Cordyceps Control total bilirubin, serum creatinine, serum urea and total cholesterol levels.
A revolutionary mushroom that can actually develop rejuvenate complete liver function and health over the period of its therapy sessions. The Cordycepin (3'deoxyAdenosine) is a strong molecular binder of ATPs that act as nutrition at a very cellular level.